MN64 is a potent and selective tankyrase (TNKS) inhibitor (IC50 values of 6 and 72 nM for TNKS1 and TNKS2 respectively). It has no effect on PARP-1 or PARP-2 (IC50 > 19 μM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/β-catenin pathway in a cell-based reporter assay. MW: 264.32. Purity ≥98% by HPLC