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Description
RSK2(Tyr529) Polyclonal Antibody, FITC Conjugated. ? Target Background: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 a
Immunogen
KLH conjugated synthetic phosphopeptide derived from human RSK2 around the phosphorylation site of Tyr529. Immunogen Range: 510-550/740