Purity > 90% as determined by SDS-PAGE. MW: 22.8kDa. Full Length: 1-61aa. N-terminal 6xHis-SUMO-tagged. Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps). Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Short name:Fas-2; Short name:Fas2; Alternative name (s); Acetylcholinesterase toxin F-VII; Fasciculin-II; Short name:FAS-II; Toxin TA1