Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000
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Description
DUSP10 Monoclonal Antibody (OTI2H1). Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in bo
Immunogen
n/a
Other Names
MKP-5, MKP5, dual specificity phosphatase MKP-5, dual specificity protein phosphatase 10, map kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5, serine/threonine specific protein phosphatase