Immunohistochemistry (Frozen): 1:10-1:500, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 2 μg/mL
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Description
Rb (Cleaved DRb-p70) Monoclonal Antibody (172C1094). The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).