A ROCK-I and II inhibitor (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase; suppresses the activation of ROCK substrates MLC-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 at 100 nM in cancer cells
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
1342278-90-3 1342278-94-7 ROCK inhibitor cancer migration invasion metastasis Rho-associated kinase ROCK1 ROCK2 biochemical signal transduction intracellular signaling RKI1447 ATP binding site suppress activation substrate myosin light chain MLC-2 phosphatase PP1 MLC2 regulatory subunit MYPT-1 MYPT1 mediated MDA-MB-231 breast cancer cells pyridylthiazolyl-urea