TATA-Binding Protein-Associated Phosphoprotein (DR1) (AA 1-176) protein (Biotin)
Description
DR1 is a phosphoprotein that inhibits both basal and activated levels of transcription. DR1 is phosphorylated in vivo which affects its interaction with TBP. DR1 has a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. By selectively repressing polymerases II and III, DR1 alters the physiological balance of transcriptional output in favor of polymerase I Synonyms: NC2, NC2-BETA, Negative cofactor 2-beta