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Description
This antibody is raised against a synthetic peptide around phosphorylated Tyr1150 / Tyr1151 of Insulin Receptor (signal peptide cleaved form of P06213-2), which is identical to the sequence around phosphorylated Tyr1135 / Tyr1136 of IGF1R (signal peptide cleaved form). Although exhibiting a preference for IR/IGF-1R, this antibody has been shown by both peptide competition and protein blotting to react with other dual phosphotyrosine motifs from proteins such as c-Met and Shc.
Immunogen
Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosines 1162 and 1163 of the human insulin receptor (IR)