TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW: 20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF. Purity ≥90%
Size
50 μg
Concentration
0.25 mg/ml
Applications
RUO
Other Names
Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c