Recombinant Human WD repeat-containing protein 5 (WDR5)
Description
Purity > 90% as determined by SDS-PAGE. MW: 52.5kDa. Full Length of Mature Protein: 2-334aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.