An antibiotic; reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner when administered at doses ranging from 25-100 mg/kg; prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis; prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection