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Description
Mouse Anti-CHEK2 Recombinant Antibody (CBXC-0414). This product is a mouse antibody that recognizes CHEK2. The antibody CBXC-0414 can be used for immunoassay techniques such as: IF, IP, WB. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to