Recombinant Human Mucosal addressin cell adhesion molecule 1
Description
19-317aa; Extracellular Domain. MW: 47.39kD. Purity >90% as determined by SDS-PAGE. Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion st
Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. Leung E., Greene J., Ni J., Raymond L.G., Lehnert K., Langley R., Krissansen G.W. Immunol. Cell Biol. 74:490-496(1996)