Immunofluorescence: 20 μg/mL, Western Blot: 1-2 μg/mL
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Description
KEAP1 Polyclonal Antibody. KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-Kappa-B activity by targeting IKKBeta degradation. Mutation of the KEAP1 gene is found in lung ca
Immunogen
n/a
Other Names
KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2