Immunoprecipitation: 2-5 μg/mg lysate, Western Blot: 1:2,000-1:10,000
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Description
CARMA1 Polyclonal Antibody. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced
Immunogen
n/a
Other Names
CARD-containing MAGUK protein 1; bcl10-interacting maguk protein 3; card-maguk protein 1; carma 1; caspase recruitment domain-containing protein 11