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Description
MEF2A(myocyte enhancer factor 2A) also known as RSRFC4, RSRFC9,is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. Several alternative splice variants of MEF2A were identified that were predicted to encode different protein products. Using immunofluorescence, MEF2A protein was detected in the nuclei of skeletal and cardiac muscle cells. The MEF2A gene is mapped on 15q26.3. MEF2A may be involved in induction of muscle differentiation and MEF2C in maintenance of the differentiated state. Coimmunoprecipitation assays indicated that GEF bound both MEF2A and MEF2D in vitro, and MEF2D interfered with the transcriptional activation promoted by the cooperative interaction of MEF2A and GEF. A transcriptional repressor form of MEF2A that is sumoylated at lys403 promoted dendritic claw differentiation.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2A(358-374aa MLSLGQVSAWQQHHLGQ), different from the related mouse and rat sequences by one amino acid.