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Description
Tim-3 Antibody. As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. It is known to synergize with Toll-like receptors and is thought to regulate Th1 and Th17 cytokine secretion.
Immunogen
Synthetic peptide surrounding amino acid residue 285 of human Tim-3
Other Names
tim-3, tim3, tim 3, TIMD3, TIMD-3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell membrane protein 3