Inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively); suppresses proliferation of Bcr/Abl-positive K562 and Ku812 CML cells (IC50s = 0.2 and 0.13 nM, respectively) and induces tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl