Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat, human
Isotype
n/a
Format
affinity purified
Size
50 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC)
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Description
A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB . It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs . Constitutive expression of A20 is observed in lymphoid tissues , but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha , IL-1 , phorbol esters , and LPS . Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members , and interaction with the NF-kappaB inhibiting protein ABIN . Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions . The amino-terminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation . Synonyms: A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2,