TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term)
Clone
3D10-G10-B6
Host Species
Mouse
Reactive Species
human
Isotype
n/a
Format
affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reportedMay be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesisSubunit structure: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7, during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2Sequence similarities: Contains 1 PP2C-like domain
Immunogen
Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.