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Description
APC anti-mouse IL-17RB. IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family. ?IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R.? It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells.? It binds IL-17B and IL-17E (IL-25) but not IL-17A or C. ?Its interaction with IL-25 has a higher affinity than that with IL-17B.? Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1.? IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.
Immunogen
Recombinant mouse IL-17RB - Fc chimera (human IgG1)