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Description
TRPC4AP Monoclonal Antibody (3G4). Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Immunogen
n/a
Other Names
TRPC4AP; transient receptor potential cation channel, subfamily C, member 4 associated protein; C20orf188; TRRP4AP; TRUSS; TRP4-associated protein; TRPC4-associated protein; short transient receptor potential channel 4 associated protein; tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein