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Description
Rabbit polyclonal to TLR9. Toll-like receptor 9 (TLR9) is a single-pass type I membrane protein belonging to the Toll-like receptor family. TLR9 is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidinephosphate-guanosine (CpG) dinucleotides. TLR9 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Furthermore, TLR9 controls lymphocyte response to Helicobacter infection.