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Description
Fto is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Fto has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Fto has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Fto has no activity towards 1-methylguanine and no detectable activity towards double-stranded DNA. Fto requires molecular oxygen, alpha-ketoglutarate and iron. Fto contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Synonyms: Polyclonal Fto antibody, Anti-Fto antibody, fat mass and obesity associated antibody, AW743446 antibody, mKIAA1752 antibody.
Immunogen
Fto antibody was raised in rabbit using the N terminal of Fto as the immunogen