Immunocytochemistry: 20 μg/mL, Immunofluorescence: 20 μg/mL, Western Blot: 1 μg/mL
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Description
TRIP6 Polyclonal Antibody. TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a PDZ-binding motif, a Crk SH2-binding motif and/or other protein interacting domains. TRIP6 regulates NF-kappa-B activation and interacts with RICK and TRAF2, proteins that are involved in TNF signaling. TRIP6 antagonizes Fas-induced apoptosis and promotes Fas-mediated cell migration in apoptosis-resistant glioma cells via Src-dependent phosphorylation of TRIP6 at Tyr-55.
Immunogen
n/a
Other Names
tcag7.1300, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1; OPA-interacting protein 1; TR-interacting protein 6; thyroid hormone receptor interacting protein 6; thyroid receptor-interacting protein 6; zyxin related protein 1