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Description
Rabbit IgG polyclonal antibody for Nuclear receptor coactivator 1(NCOA1) detection. Tested with WB in Human. No cross reactivity with other proteins. The nuclear receptor coactivator 1 (NCOA1), also known as SRC1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter. It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone. What's more, SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.
Immunogen
E.coli-derived human KAT13A recombinant protein (Position: H614-Q826). Human KAT13A shares 92% amino acid (aa) sequence identity with mouse KAT13A.
Other Names
Nuclear receptor coactivator 1;NCoA-1;2.3.1.48;Class E basic helix-loop-helix protein 74;bHLHe74;Protein Hin-2;RIP160;Renal carcinoma antigen NY-REN-52;Steroid receptor coactivator 1;SRC-1;NCOA1;BHLHE74, SRC1;