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Description
STEP (Protein-tyrosine phosphatase striatum-enriched) is a neural-specific protein-tyrosine phosphatase. It is also known as PTPN5 (tyrosine-protein phosphatase, non-receptor type 5). STEP immunoreactive areas are most intense in the regions of the CNS receiving a dopaminergic input (e.g. striatum, basal ganglia). STEP is part of the NMDA receptor (R) complex and inhibits NMDAR single-channel activity and NMDAR-mediated synaptic current. Phosphorylation of STEP, via D1 and PKA activation by dopamine, decreases the activity of STEP by reducing its affinity for substrate. This PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PTPN5.
Immunogen
Human PTPN5.
Other Names
Neural-Specific Protein-Tyrosine Phosphatase; Striatum-Enriched Protein-Tyrosine Phosphatase; Step; Ptpn5; protein tyrosine phosphatase; non-receptor type 5 (striatum-enriched); FLJ14427; PTPSTEP; Tyrosine-protein phosphatase non-receptor type 5