Purity: > 90% by SDS - PAGE Format: In 20mM Tris 7.5, 0.1M NaCl, 1mM DTT. The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E.coli and purified by using conventional chromatography techniques.
Size
0.5mg, 100ug, 20ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
Down syndrome candidate region 1, Down syndrome candidate region 1, Down syndrome critical region protein 1, adapt78 protein, calcipressin 1, Calcipressin 1 isoform b, Down syndrome candidate region 1