Recombinant Cricetulus griseus Protein disulfide-isomerase (P4HB)
Description
Purity > 90% as determined by SDS-PAGE. MW: 59kDa. Full Length of Mature Protein: 20-509aa. N-terminal 6xHis-tagged. Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
PDI; Alternative name (s); Prolyl 4-hydroxylase subunit beta; p58