Purity: > 85% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl, 0.1mM PMSF . Lin-28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Recombinant Lin28 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Size
250ug, 50ug, 10ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
Zinc finger CCHC domain-containing protein 1, CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1, Zinc finger CCHC domain-containing protein 1 AL024421.Lin 28, Lin 28 homolog, Tex17, Lin28a, Lin 28 homolog (C, elegans), Lin 28 homolog A, RNA binding protein lin 28, Zinc finger CCHC domain containing protein 1.