Purity: > 95 % by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT,10% glycerol. Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. Recombinant human Visinin-like protein-1 was expressed in E.coli and purified by using conventional chromatography.
Size
0.5mg, 100ug, 20ug
Concentration
n/a
Applications
SDS-PAGE
Other Names
VILIP, VILIP-1, VLP-1, HLP3, VSNL1, Hippocalcin like protein 3, HLP 3, HPCAL 3, HPCAL3, HuVISL1, Neurocalcin alpha, NVL 1, NVL1, VILIP, Visinin.Visinin like 1, Visinin like protein 1.VISL 1.