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Description
Antibodies to HLA class I α1 domain trigger apoptosis of activated T-cells and also control the growth/survival of human B lymphocytes. Addition of mAb 90 strongly inhibits the proliferation of CD40-activated total tonsillar B cells, purified naive, germinal center and memory B-cell subsets. mAb 90 binds to an epitope of the α-1 domain of HLA class I heavy chain induces apoptotic cell death of activated but not resting peripheral T lymphocytes. (Genestier L. et al., 1997 Blood, 90, 726-35; Genestier L. et al. 1997, Blood, 90, 3629-3639)