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Description
IL-17 (cytotoxic T lymphocyte associated antigen 8) is a CD4+ T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. PBMC isolated from a human healthy donor were cultured in the Blood B Booster system (DDXK-HuBBB, Dendritics). Immortalized antibody-secreting clones were screened on the basis of human IL17A recognition. HAA10E10 is a human monoclonal antibody specific for IL17A with agonist properties (enhances IL17A biological activities). (Fossiez F et al, 1996 ; J. Exp. Med., 183:2593-2603)