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Description
CD8 exists in two forms: a CD8 heterodimer composed of a a chain and a b chain; and a homodimer of two a chains (CD8a = Lyt2, Ly2, OX8). The heterodimer is found on essentially all thymocytes and the ``suppressor/cytotoxic'' subpopulation of mature T lymphocytes. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC-Class I-restricted CD8+ T cells. CD8 is required for the development of cytotoxic T cells.(Ledbetter JA et al, 1979, Nat. Rev. Immunol., 47, 63: 425-30; Nakauchi H et al, 1995, PNAS 85, 5126-5130)