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Description
MEF2A Polyclonal Antibody. The myocyte enhancer factors-2 (MEF-2) family of transcription factors associate with a variety of co-repressors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four distinct family members arise from alternatively splices transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF-2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the 4 transcripts implies functional distinction for each during embryogenesis and development.