Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (C-Term)
Clone
1A1
Host Species
Mouse
Reactive Species
human
Isotype
IgG1
Format
antigen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunoprecipitation (IP)
Reviews / Ratings
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Description
Parkinson's Disease (PD) is a relatively common neurodegenerative disorder, which is characterized by the loss of midbrain dopamine (DA) neurons and the presence of Lewy bodies, proteinaceous cytoplasmic inclusions that are abundantly enriched in ubiquitin. A number of potential substrates for parkin, which may be involved in the pathogenesis of PD, have been identified. Autosomal Recessive Juvenile Parkinsonism (ARJP) is a recently described form of Parkinson's Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Description: Supernatant. Synonyms: Polyclonal Parkin antibody, Anti-Parkin antibody, AR JP antibody, E3 ubiquitin protein ligase parkin antibody, FRA6E antibody, LPRS 2 antibody, LPRS2 antibody, PARK 2 antibodyPARK2 antibody, Parkinson disease (autosomal recessive juvenile) 2 antibody, Parkinson disease protein 2 antibody, Parkinson juvenile disease protein 2 antibody, PDJ antibody, PRKN 2 antibody, PRKN antibody, PRKN2 antibody, Ubiquitin E3 ligase PRKN antibody.
Immunogen
Parkin antibody was raised in mouse using a synthetic peptide corresponding to the Cterminal part of human parkin (AYRVDERAAEQARWEAA) as the immunogenSupernatant