Immunoprecipitation: 2-10 μg/mg lysate, Western Blot: 1:2,000-1:10,000
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Description
ASAP2 Polyclonal Antibody. ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Us
Immunogen
n/a
Other Names
AMAP2, centaurin, beta 3, CENTB3, DDEF2, development and differentiation enhancing factor 2, development and differentiation-enhancing factor 2, KIAA0400, PAG3, PAP, Pap-alpha, paxillin-associated protein with ARF GAP activity 3, PYK2 C terminus-associated protein, pyk2 C-terminus-associated protein, SHAG1