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Description
Recognizes CD152 (CTAL-4). The ``cytolytic T-lymphocyte-associated antigen 4'' (CTLA-4) is a member of the Ig superfamily (1) and its extracellular domain exhibits a single Ig V-like region. It was originally identified as a fourth cDNA product, during a search for genes that were thought to be specifically expressed in cytotoxic T lymphocytes (1). CTLA-4 has a molecular weight close to 45kDa (2). It is mainly expressed as a monomer (4), but may also be expressed as a disulfide-linked homodimer (2,3). CTLA-4 belongs to the CD28 receptor family (4,5).
Immunogen
Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig)