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Description
CD52 Antibody (clone YTH34.5, RPE) LS-C188151. Specificity: Reacts with the human CD52 antigen, also known as CAMPATH-1. The CD52 antigen is a remarkably small but heavily glycosylated peptide attached to the cell surface membrane via a GPI link. The apparent molecular mass of the native antigen on SDS-PAGE is 25-29kD, considerably reduced following N-glycanase treatment. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. Humanized versions of CAMPATH-1 specific antibodies are currently in clinical trials for the treatment of a range of lymphoid malignancies ;.