bovine, canine, equine, guinea pig, human, mouse, rabbit, rat, zebrafish
Isotype
n/a
Format
purified
Size
100 μl
Concentration
n/a
Applications
Immunohistochemistry: Assay-dependent, Western Blot: 1.0 μg/mL
Reviews / Ratings
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Description
GAD67 Polyclonal Antibody. GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist fo