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Description
Purified anti-FOXP1 (Forkhead Box P1). FOXP1 (Forkhead Box P1) is a transcription regulator, which plays an important role in the brain, cardiac, lung, and lymphocyte development. Mutations in FOXP1, which are located at 3p13, have been reported in patients with global developmental delay (GDD), intellectual disability (ID), and speech defects. FOXP1 is targeted by recurrent chromosome translocations and its overexpression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localizes to a tumor suppressor locus at 3p14.1 and the loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumor suppressor in other tissue types. Recent studies also suggest that in embryonic stem cells (ESC), specific isoforms of FOXP1 help maintain the ESC pluripotency and stimulates the expression of transcription factor genes that are required for pluripotency such as OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation.
Immunogen
Full length recombinant human FOXP1 protein.
Other Names
Forkhead Box P1, Fork Head-Related Protein Like B, QRF1, hFKH1B, MFH, 12CC4, HSPC215