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Description
Rat Anti-Mouse Foxp3-FITC. Specificity: Mouse Foxp3 (Mr ~57 kDa). Does not cross react with Human Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other acti
Immunogen
N-terminal recombinant Mouse Foxp3Characterization: To insure acceptable performance, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative flow data are included in this product insert
1. Fehervari Z, Sakaguchi S. Development and function of CD25 CD4 regulatory T cells. Curr Opin Immunol. 2004 Apr; 16(2):203-8. Review. 2. Gallimore A, Sakaguchi S. Regulation of tumor immunity by CD25 T cells. Immunology. 2002 Sep; 107(1):5-9. Review. 3. Zhang L, Zhao Y (June 2007). The regulation of Foxp3 expression in regulatory CD4( )CD25( )T cells: multiple pathways on the road. J. Cell. Physiol. 211 (3): 590-597. 4. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, K