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Description
Purified anti-MINA. MINA, also known as Mineral dust-induced gene (MDIG), is a member of the JmjC family of proteins and can act as a histone lysine demethylase and a ribosomal histidine hydroxylase. MINA is implicated in the demethylation of K9 trimethylated histone H3 (H3K9me3), regulating cell proliferation and survival. MINA has been suggested to be a novel oncogene associated with a variety of cancers. Elevated expression of MINA in human tumors has been linked to malignancy and poor prognosis. MINA has been identified as a transcriptional co-repressor of IL-4 gene and participates in the regulation of Th2 differentiation and Th2 bias. MINA appears to be a regulator of the Treg/Th17 balance by promoting differentiation of Th-17 cells and inhibiting FOXP3 expression.
Immunogen
Partial recombinant protein (300-465 aa) expressed in E. coli.
Other Names
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, 60S ribosomal protein L27a histidine hydroxylase, Histone lysine demethylase MINA, MYC-induced nuclear antigen, Nucleolar protein 52 (NO52), Ribosomal oxygenase MINA (ROX), MDIG