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Description
Purified anti-EOS. EOS, also known as IKZF4 (Ikaros family zinc finger 4), is a member of the Ikaros family of zinc finger transcription factors, which are key transcriptional repressors during development of lymphocytes. Each of the five Ikaros family members (Ikaros, Helios, Aiolos, Eos and Pegasus) has N-terminal and C-terminal zinc-finger motifs responsible for DNA binding and dimerization, respectively. EOS is a highly conserved DNA-binding protein that recognizes the typical 5'WGGAAT-3' Ikaros-binding sequence. EOS has been implicated in the development of lymphoid cells and nervous systems, as well as mediating FOXP3-dependent gene silencing in CD4+ regulatory T cells though interacting with FOXP3 and CTBP1.
Immunogen
Partial human EOS recombinant protein (271-520 a.a.) expressed in E. coli.
Other Names
Ikaros family zinc finger protein 4 (IKZF4), KIAA1782, ZNFN1A4