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Description
FITC anti-rat CD62L monoclonal antibody recognizes rat leukocyte selectin (L-selectin). CD62L is expressed constitutively on leukocytes and is expressed by a subset of thymocytes predominantly single positive CD4 or CD8 cells and a majority of lymph node cells in rats. CD62L binds well to O-glycans present on certain glycoforms of the mucins GlyCAM-1, CD34 and MAdCAM-1. CD62L is reported to be capable of reported to be capable of capable of transducing signals when cross-linked and has been shown to stimulate -integrin-mediated adhesion when bound to soluble GlyCAM-1. [1] L-selectin expressing CD4 CD8 thymocytes were shown through adoptive transfer to protect rats from insulin-dependent diabetes. CD4 CD8 thymocytes must mature to the stage of L-selectin expression before they can mediate normal T cell function. [2] Sensitive detection systems may be required on some tissues as expression of rat CD62L is weak.