Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
ROR1(receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase, receptor-related 1(NTRKR1), Tyrosine-protein kinase transmembrane receptor ROR1, is a member of thereceptor tyrosine kinase-like orphan receptor(ROR) family. NTRKR1 encodes a predicted 937-amino acid protein. A 6-kb NTRKR1 mRNA is expressed strongly in human heart, lung, and kidney, but weakly in the CNS. However, a truncated 2.4-kb mRNA lacking extracellular and transmembrane domains was strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ROR1(904-918aa NKSQKPYKIDSKQAS), different from the related rat and mouse sequences by one amino acid.