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Description
Purified anti-RORg. RORγ (Retinoid-related orphan receptor gamma) belongs to nuclear hormone receptor family, NR1 subfamily. RORγ has two isoforms: RORγ1 and RORγ2 (also known as RORγt). RORγ1 contains 516 amino acids and RORγt contains 495 amino acids (RORγt lacks the amino terminus). RORγ1 is expressed in thymus, kidney, liver, muscle and brown fat tissue but not white fat tissue. RORγt is specifically expressed in CD4+/CD8+ thymocytes and lymphoid tissue inducers (LTi). RORγ plays critical roles during thymopoiesis, T cell homeostasis, lymph nodes and Peyers patch development. Among two isoforms, RORγt is well studied and it promotes thymocyte differentiation into pro-inflammatory Th17 cells.