Purity ~90% (SDS-PAGE). GMP synthase, also known as GMPS, is involved in purine biosynthesis. Existing as a homodimer, GMPS catalyzes the last step in the GMP synthesis pathway, namely the ATP-dependent amination of XMP to GMP. GMPS contains one GMP-binding domain and one glutamine amidotransferase type-1 domain through which it conveys its catalytic activity. Chromosomal translocations involving the gene encoding GMPS are associated with acute myeloid leukemias, suggesting a possible role for GMPS in carcinogenesis. Source: Recombinant protein corresponding to aa1-693 from human GMPS, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~79.2kD (717aa) AA