Inhibits BMP type 1 receptor-induced phosphorylation of SMAD1/5/8 (IC50 = 4.9 nM); shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
DM-3189 SMADs SMAD1/5/8 BMP bones morphogenetics proteins TGF-β inhibitors ALK1 ALK2 ALK3 ALK6 cancers formations ALK-1 ALK-2 ALK-3 ALK-3 ALK-6 ALKs SMAD-1/5/8 TGF-beta TGF-.beta. TGF-b TGFs LDN-193189 LDN193189 inhibits inhibitions drosophila mothers against decapentaplegic Mad genes C. delegans Sma activin receptors like kinases receptor-like in vitro kinases type I one fibrodysplasia ossificans hyperossification disorders osteogenesis prostates tumors metastases DM3189 DM 3189 transcriptions factors bone-related intracellular signaling