Inhibits maize HDACs: HD2, HD-1B, and HD-1A (IC50s = 7.5-16 nM) and reduces TNFα, IL-1α, and IL-1β production (IC50s = 10-22 nM); inhibits activity of cells expressing JAK2V617F (IC50s = 1-10 nM), which are implicated in the pathophysiology of many myeloproliferative diseases
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
497833-27-9 givinostat histones deacetylases HDACs inhibitors inhibits inhibition pro-inflammatory cytokines janus kinases 2 JAK2 myeloproliferative diseases antitumor antiinflammatory anti-inflammatory anti inflammatory proinflammatory pro inflammatory HD2 HD-1B HD1A HD1B HD1A HD 1B HD 1A TNFα IL-1α IL-1β cytokines tumors necrosis factors interleukins cells JAK2V617F enzymes polycythaemia vera ITF-2357 ITF2357